High precision microdispensing from picoliters to nanoliters

10 pL to 800 pL per drop

The technology, as patented by SCIENION, is called sciDROP PICO, and covers dispensing a liquid sample from 10 pL* to 800 pL per drop.

In combination with sciDROP NANO, the total volume range between 10 pL and 100 μL is covered by a single sciFLEXARRAYER instrument.

*results obtained with optimized samples and configuration.

Non-contact technology offers a number of benefits over contact spotting

  • Homogenous spot morphology
  • No damage to sensitive surfaces, as can result from contacting metal pins
  • Dispensing into very small cavities
  • Drop volume is fully controlled by implementing a proprietary vision-based algorithm

Piezo Dispense Capillaries

SCIENION’s sciDROP PICO is a state of the art non-contact dispensing technology based on piezo driven pulses on an inert glass capillary.

This enables accurate and precise droplet deposition under various conditions.

All Piezo Dispense Capillaries (PDCs) aspirate and dispense liquid at the picoliter scale. We will determine the best PDC size and coating combination for your specific application.

Benefits of sciDROP PICO

  • Gentle acoustic dispensing of samples, no shear stress
  • Living cells are successfully dispensed
  • No added glycerol is needed in the system liquid
  • Precise drop volume control with unique visual detection
  • Absolute zero dead volume
  • No crystallization of sample inside the tip due to a round orifice
  • No satellite drops due to full drop ejection parameters control

Wide Range of Liquids

The sciDROP PICO option, together with SCIENION´s surface coating technology, provides access to a broad field of applications with high accuracy and precision dispensing a wide range of liquids:

Biomolecules using water based printing buffers

Small molecules using a range of organic solvents

A large number of other various viscous liquids

Dispensable Media

Thanks to our surface characterization expertise, we have developed inert glass Piezo Dispense Capillaries (PDCs) which can be coated to improve the quality of the dispensed solution. We have worked very successfully with the following solutions but this list is not exhaustive.

Piezo dispensing Non-contact
Capillary orifice 35 – 75 µm
Spot frequency 200 – 1500 Hz
Typical spot size 80 – 250 µm
Average CV of drop volumes <2%, typically < 0.5 %
Typical pitch (spacing) Freely scalable (> 50 µm)
Capillary materials Borosilicate glass, TEFLON® tube, PEEK fitting
Materials (in contact with medium) PEEK, stainless steel, corundum
Viscosity of spotable media 0.4 – 5 (mPa.s)
PDC 60 220-300 pl
PDC 70 300-360 pl
PDC 80 360-440 pl
PDC 90 440-520 pl
PDC 100 520-600 pl
PDC 110 600-800 pl
With coating types
Type 1 Aqueous solutions and organic solvents
Type 2 Samples containing organic solvents like DMSO, DMF etc. and protein mixtures (lysates, allergens etc.)
Type 3 Samples containing protein solutions and organic solvents like methanol, isopropanol, acetonitrile etc.)
Type 4 Protein solutions and Sol-Gel samples
Coating special According to customer specifications

Contact us to discuss which PDC type is optimal for your application.