Recent advances in epigenetics have revealed the complexity of the “histone code,” yet most measurements still rely on bulk analyses that obscure cell-to-cell variation. What if the most important regulatory signals are hidden in this averaging?
In this webinar, Ronald Cutler, Ph.D, introduces a mass spectrometry-based approach for profiling histone post-translational modifications at true single-cell resolution using the cellenONE platform. His team at Albert Einstein College of Medicine, New York, directly quantified dozens of histone modification states and uncovered striking chromatin heterogeneity in seemingly uniform cell populations.
Join us to learn about:
- Why studying the chromatin states at the single-cell level is crucial in epigenetic research
- How the cellenONE platform enables high-throughput sample preparation for omics studies
- How single-cell profiling reveals differential responses to epigenetic perturbations, uncovering subpopulations and coordinated modification patterns invisible in bulk data
- How this approach opens the door to studying epigenetic regulation, cellular states, and therapeutic responses at unprecedented resolution