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SCIENION US, Inc. receives ISO 13485 certification

SCIENION US, Inc, a leading global provider of microarray services for custom assays, today announced that its entire portfolio of microarray services is now manufactured under ISO 13485 certification, an internationally recognized standard for quality management systems (QMS). The certification is accredited by TÜV SÜD America Inc.
Monmouth Junction, NJ, USA, March 18, 2015: ISO 13485:2003 specifies requirements for a quality management system where an organization needs to demonstrate its ability to provide medical devices and related services that consistently meet customer requirements and regulatory requirements applicable to medical devices and related services.
"SCIENION had already earned a global reputation for producing very high quality spots, always emphasizing quality in every step of our manufacturing process. Today, we’re very pleased to be adding the external validation of our ISO 13485-compliant Quality Management System," said Dr. Claude Dufresne, SCIENION US, Inc President and Chief Business Officer.
"As the leading provider of microarray-based services for a wide variety of applications, we remain committed to our customers in providing the highest quality of products and services in this market," said Holger Eickhoff, SCIENION CEO. "We believe that SCIENION is now in a stronger position to take the next step with our customers pursuing regulatory clearance of microarray-based testing platforms in the Diagnostics Market."
SCIENION’s microarray services at the SCIENION AG facilities have been manufactured in compliance with the ISO 9001:2008 standard since December 2008.

About SCIENION
SCIENION AG and its US subsidiary SCIENION US, Inc. provide systems and services for the contact-free printing of biological and chemical agents for diagnostics, pharmaceutics, veterinary, plant and food analytics and research. Addressing the dynamically increasing needs for miniaturization and multiplex analyses, SCIENION offers a unique technology portfolio that has been continuously expanded over one decade. SCIENION provides flexible solutions for research and development, wherein solutions for production purposes are customized. Systems and software are characterized by their versatility, precision and robustness. The company is a renowned specialist for ultra-low volume liquid handling, particularly for the handling of precious and sensitive compounds of biological or chemical origin. SCIENION’s dispensers allow for contact-free and precise drop spotting in the pico- to micro-liter range and are optimally suited for microarray based analytics – such as for tests with DNA, oligonucleotides, peptides, proteins, antibodies, glycans or for dispensing cells onto various substrates. The company operates from two sites in Germany, Dortmund and Berlin, and has a subsidiary in New Jersey, USA.

Contact
SCIENION AG
Almut Gebhard
Otto-Hahn-Str. 15
D-44227 Dortmund
Phone +49 (0)30 – 6392 1700
Fax +49 (0)30 – 6392 1701[email protected]www.scienion.com

SCIENION introduces line dispenser for membrane materials with full drop formation control at Medica 2013

SCIENION AG today announced the launch of the sciLINER, the first dispenser to print lines on membranes with full visual drop detection.
Dortmund and Berlin, Germany, November 13, 2013: With up to four channels, a minimum dispensing volume of 0.1 µl/cm and a flow rate of up to 8 ml/min the sciLINER represents an economical entry unit enabling the production of lateral flow devices or other membrane-based materials. With its printing speed of 20 seconds per sheet it covers production from small to medium throughput. It can be operated in either aspirate dispense or bulk dispense modes to produce continuous lines with a width from 0.5 to 5 mm. In contrast to current technologies, the sciLINER allows for the online monitoring of drop formation and offers integrated drop volume measuring. Both are important features when sensitive biological materials such as antigens, antibodies or DNA are deposited on substrates used in the diagnostics industry. The non-contact dispenser loads all membranes and flat targets with a size of up to 150 x 300 mm. “This is our first product specifically geared towards the point of care testing market”, says Dr. Holger Eickhoff, CEO of SCIENION AG. “As with all our technologies, this new technology does not only meet present needs for R&D efforts but, with drop control mechanisms, also forms the basis for a stable production of point of care tests based on membrane materials.”

Security Protocols to Look for in Canadian Betting Sites

When it comes to online betting, security is paramount. As the popularity of online gambling continues to rise, ensuring that your personal and financial information is protected has never been more crucial. In Canada, where sports betting and online casinos are thriving industries, understanding the security protocols in place at betting sites is essential for a safe and enjoyable experience.

In this article, we delve into the key security protocols that you should look for when choosing a Canadian betting site. From encryption methods to data protection measures, we explore the top considerations to keep in mind to safeguard your sensitive information. Join us as we navigate the world of online betting security and empower you to make informed decisions when selecting a platform for your wagering adventures.

Importance of Robust Security Measures in Online Betting

When it comes to selecting a reputable Canadian betting site, it is crucial to prioritize platforms that adhere to stringent security protocols. One key security measure to look for is SSL encryption, which ensures that all data transmitted between your device and the website is encrypted and protected from unauthorized access. Additionally, reputable betting sites in Canada implement two-factor authentication to add an extra layer of security to your account. This feature typically requires users to provide a second form of verification, such as a unique code sent to their mobile device, before accessing their account.

Furthermore, it is essential to choose betting sites that are licensed and regulated by official authorities such as the Kahnawake Gaming Commission or the British Columbia Lottery Corporation. These regulatory bodies ensure that the betting site operates in compliance with strict security standards and fair gaming practices. Another crucial security protocol to look for is secure payment methods, including reputable options like Interac, PayPal, or credit cards, to safeguard your financial transactions. By prioritizing platforms that incorporate these security measures here, Canadian bettors can enjoy a safe and secure online betting experience.

Key Security Protocols for Ensuring Data Protection

When choosing a Canadian betting site, it is crucial to consider the security protocols in place to protect your personal and financial information. Look for sites that utilize encryption technology, such as SSL (Secure Sockets Layer), to safeguard data transmission between your device and the site’s servers. Encryption ensures that sensitive details like credit card numbers and passwords are encrypted and cannot be intercepted by malicious third parties.

Another important security protocol to look for is two-factor authentication (2FA). This additional layer of security requires users to provide two forms of verification before accessing their accounts, such as a password and a unique code sent to their mobile device. 2FA helps prevent unauthorized access even if your password is compromised, adding an extra level of protection to your betting account.

Furthermore, reputable Canadian betting sites should have robust privacy policies and data protection measures in place. Look for sites that are licensed and regulated by respected authorities like the Kahnawake Gaming Commission or the British Columbia Gaming Policy and Enforcement Branch. These regulatory bodies ensure that the betting site follows strict security standards and complies with privacy regulations to keep your information safe and secure.

Compliance with Canadian Regulations and Standards

When choosing a Canadian betting site, it is crucial to prioritize platforms that implement robust security protocols to safeguard your personal and financial information. One of the key security features to look for is SSL encryption, which ensures that all data transmitted between your device and the website is encrypted and protected from unauthorized access.

Additionally, reputable betting sites in Canada often have strict verification processes in place to verify the identity of their users. This typically involves providing proof of identity and address, which helps prevent fraudulent activities and ensures a safe betting environment for all players. Look for sites that adhere to these verification measures to enhance the security of your account.

Furthermore, two-factor authentication (2FA) is another important security protocol to consider when selecting a betting site. With 2FA, users are required to provide an additional verification step, such as a unique code sent to their mobile device, when logging in or conducting sensitive transactions. This extra layer of security significantly reduces the risk of unauthorized access to your account.

Lastly, reputable Canadian betting sites often hold licenses from respected regulatory bodies, such as the Kahnawake Gaming Commission or the British Columbia Gaming Policy and Enforcement Branch. These licenses indicate that the site operates in compliance with strict security standards and fair gaming practices, providing users with added assurance of a secure and trustworthy betting experience.

Evaluating Trustworthiness and Reliability of Betting Sites

When choosing a Canadian betting site, it’s crucial to prioritize platforms that employ robust security protocols to protect your sensitive information. Look for sites that utilize SSL encryption technology, which ensures that data transferred between your device and the website remains encrypted and secure. Additionally, reputable betting sites will have stringent verification processes in place to verify the identity of users and prevent fraudulent activities.

Furthermore, opt for betting sites that are licensed and regulated by reputable authorities such as the Kahnawake Gaming Commission or the British Columbia Gaming Policy and Enforcement Branch. These regulatory bodies enforce strict security standards to safeguard players’ personal and financial details. Additionally, sites that offer two-factor authentication add an extra layer of security to your account, reducing the risk of unauthorized access. By selecting Canadian betting sites with these security measures in place, you can enjoy a safer and more secure online betting experience.

Ensuring the safety and security of your personal and financial information is paramount when engaging in online betting activities. By understanding the key security protocols to look for in Canadian betting sites, such as SSL encryption, licensing from reputable authorities, and secure payment options, you can enjoy a worry-free betting experience. Remember to always prioritize security when choosing a betting site to protect yourself from potential risks and enjoy a seamless and protected online gambling experience. Stay informed, stay safe, and happy betting!

Assays on membrane materials have become a very popular and versatile test format for rapid point of care diagnostics since their introduction in the mid-1980s. All kinds of biological samples can be tested, for example blood, serum, urine and, more recently, also saliva, sweat or tears if the sensitivity of the test is sufficient. Typically these tests, especially in so called Lateral Flow Tests such as popular pregnancy strip tests (often referred to as “dipstick tests”) combine several advantages being quick and easy to use with no specific equipment required.
Eickhoff states: “Reproducibility in R&D and production is key to develop and produce reliable diagnostic tests. We are confident that the sciLINER, offering central dispense steps monitoring and control from test development to manufacturing, will help customers shorten time to market with their diagnostic products.”
The sciLINER will be exhibited at the SCIENION booth at MEDICA 2013, November 20-23 in Düsseldorf, Germany, booth 3A42 in hall 3.

About SCIENION AG
SCIENION AG and its US subsidiary SCIENION US, Inc. provide systems and services for the contact-free printing of biological and chemical agents for diagnostics, pharmaceutics, veterinary, plant and food analytics and research. Addressing the dynamically increasing needs for miniaturization and multiplex analyses, SCIENION offers a unique technology portfolio that has been continuously expanded over one decade. SCIENION provides flexible solutions for research and development whereas solutions for production purposes are rather customized. Systems and software are characterized by their versatility, precision and robustness. The company is renowned specialist for ultra low volume liquid handling, particularly for the handling of precious and sensitive compounds of biological or chemical origin. SCIENION’s dispensers allow for contact-free and precise drop spotting in the pico- to micro-liter range and are optimally suited for microarray based analytics – such as for tests with DNA, oligonucleotides, peptides, proteins, antibodies, glycans or for dispensing cells onto various substrates. The company operates from two sites in Germany, Dortmund and Berlin, and has a subsidiary in New Jersey, USA.

Contact
SCIENION AG
Almut Gebhard
Otto-Hahn-Str. 15
D-44227 Dortmund
Phone: +49 (0)30 – 6392 1700
Fax: +49 (0)30 – 6392 1701
[email protected]
www.scienion.com

Scienion Extends its Drop-On-Demand Product Portfolio: sciFLEXARRAYER S3 Is a Versatile Tool for R&D and the Production of High Quality Arrays

With its sciFLEXARRAYER S3 Scienion AG has launched another model of its prize winning dispensing systems for ultra-low volume liquid handling. The piezo-driven system for non-contact dispensing was particularly developed as an economical entry for academic and R&D labs.

Dortmund and Berlin, Germany, April 10, 2007: Dr. Holger Eickhoff, CEO of Scienion AG, explains: "With the sciFLEXARRAYER S3 we wanted to make our benchmark technology affordable for academic budgets. This new S3 model is based on the same drop-on-demand technology as the higher throughput systems S5 and S11 offering all proven advantages of the sciFLEXARRAYER line."

The sciFLEXARRAYER S3 is specifically designed as a versatile tool for a variety of applications in genome and proteome research including non-contact arraying of DNA and proteins, biosensor loading, the production of cell transfection arrays and the preparation of MALDI targets. The system is engineered robustly to handle the most delicate substrates in volumes from 100 picoliters up to several microliters. A user-friendly state-of-the-art software allows for a flexible and convenient design of chip layout and for programming of individual spotting routines by users new to microarraying. The sciFLEXARRAYER S3 will be presented at the Society for Biomolecular Sciences (SBS) 13th Annual Conference and Exhibition, booth #420, April 15-19, 2007 in Montreal, Canada.
About Scienion

SCIENION AG is a life science company offering complete solutions in the field of parallel bioanalytics. Customers include pharma and biotech companies as well as academic research institutions. Founded in December 2000 in Berlin as a spin-off of the Max-Planck-Institute for Molecular Genetics, the company today operates from two sites, Dortmund and Berlin. From the start, Scienion focused on biochip platform technologies. With the successful launch of the sciFLEXARRAYER dispensing system in 2003 the company focus switched to hardware. The sciFLEXARRAYER allows the aspiration of ultra-low liquid volumes from different reservoirs and contact-free micro drop delivery in the picoliter range onto a variety of carriers. Today, Scienion represents a complete solution providing company, well positioned in the field of ultra-low volume liquid handling systems including applications in genomics, proteomics and high throughput screening.

SCIENION AG
Dr. Holger Eickhoff, CEO
Otto-Hahn-Str. 15
D-44227 Dortmund
Tel.: +49 (0)30 – 6392 1700
Fax: +49 (0)30 – 6392 1701
eMail: [email protected]
PR Contact
Almut Gebhard
Strategische Kommunikation
Tel. + 49 (0)30 – 6120 1081
Email: [email protected]

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SCIENION 可行性评估步骤指南

9月 14, 2023

SCIENION，我们致力于为您提供实现应用程序目标所需的工具和资源。如果您正在考虑开发一种新的分析方法或改进现有的分析方法，我们的免费可行性评估将为您提供一个机会，让您在没有任何义务或成本的情况下对您的项目进行专家评估。

在这里，我们将向您介绍申请可行性研究的过程，以及您对我们的专家团队的期望。

填写我们的表格

进入我们官网,点击“申请测试”按钮。这将引导您进入一个包含几个简单问题的表格。

选择你的样品、基材和喷点布局

你已经决定了要分发的样品、基材类型和打印布局。以下是你需要了解的每一项内容:

  • 样本:最有可能的是，你的样品将包含捕获探针，以固定在基底上，涂抹微结构，如微针，或填充微流控设备的通道。我们可以分装DNA和寡核苷酸、抗体、蛋白质、糖类、纳米颗粒、量子点等。
  • 样本数量:在我们的免费演示点样中，我们最多可以发放10个种类样品。
  • 阵列数量: 一些基质会决定阵列的数量和分配的位置，但在其他基质中，可以根据你的应用目标来指定。
  • 所需喷点大小: 这将是许多参数的结果，如基质或功能化或环境。我们将帮助您在基板上达到预期的尺寸。
  • 所需滴液量：SCIENION有多种喷点技术，支持从低皮升到低微升的动态喷点范围。
  • 所需的斑点尺寸：这将是许多参数的结果，如基质或功能化，或环境。我们将帮助您实现预期
  • 打印布局/图案: 3×3、5×5、12×12，还是任意图案？我们将在尽可能短的时间内实现您想要的布局。
  • 预处理和后处理：您的点样样本应该如何存储？您的基材需要表面活化吗？让我们知道如何正确处理您的样品和基质。

Schedule a call with our scientists

If you’re still unsure about the right approach – don’t worry. After a quick call with one of our scientists, you will gain much more clarity. So regardless of where you are today, schedule a call with our team to discuss your application.

收到你的演示报告

在测试之后，你会收到一份演示报告，其中描述了在对你的样品进行工作时应用的材料、方法和条件。这份报告将帮助你评估点样的性能并指导你的下一步行动。

探索SCIENION的产品组合

在SCIENION，我们使用各种支持形式，包括玻璃或聚合物载玻片、96孔板、生物传感器、微流控盒、膜、微针贴片等。如果您不确定哪种格式最适合您，我们可以先在SCIENION的产品系列中的基质上点样。可以试试我们的玻璃和聚合物载玻片（sciCHIP）或为微阵列点样优化的96孔板（sciPLEXPLATEs），并考虑使用sciREADER进行比色或荧光读出。

微针——在药物递送和POC诊断方面具有巨大潜力的微型装置

9月 14, 2023

微针有可能在药物输送和诊断方面彻底改变医疗保健行业。这些微针小到肉眼无法看到，设计用于通过皮肤输送药物而不会引起疼痛。与注射或口服药物等传统方法相比，微针提供了一系列优点。它们具有微创性，甚至可以用于通过皮肤检测具有临床意义的物质。这篇博客文章将深入研究微针的世界，探索它们的潜力、好处、应用和挑战，以及它们如何准备彻底改变药物递送和诊断。

简介

微针是非常微小的微型针，长度通常在50至900µm之间。它们最初是在1976年提出的一种无痛和无创的药物递送方法 (1). 基于微针的器件是使用微制造技术制造的，由阵列中的尖锐突起组成。虽然最早的版本是由硅、金属或玻璃制成的，但最近的模型是由可生物降解和水凝胶基聚合物制成的。1998年，佐治亚理工学院的Mark Prausnitz指出，微针适合通过穿透人体皮肤的最上层进行透皮给药 (2).

微针类型

目前市场上有多种类型的微针。图 1 展示了针对不同应用开发的不同设计的微针。

图 1：将微针应用于皮肤以达到给药目的的方法示意图（改编自参考文献图 1）。(15)

固体微针  通过穿透皮肤发挥作用。这些微针一旦被拔出，就会留下微孔，可通过透皮贴片将药物涂抹在这些微孔中。

涂层微针  可将药物直接涂抹在针头阵列上，而无需使用贴片或涂抹器。一旦被体液水化，药物就会释放到皮肤中。

溶解性微针  含有可生物降解聚合物中的药物，可溶解在皮肤内部。

空心微针  具有储液器，可通过扩散或压力输送药物。

水凝胶形成的微针   包含一个药物储存器和一种膨胀材料，后者通过吸收膨胀基质中的间隙液来扩散药物。

微针应用

微针有多种用途，例如

药物和疫苗输送

用于糖尿病管理的胰岛素输送

胰岛素给药用于糖尿病管理是一项被广泛研究的应用 (3). 传统的每天多次注射的方法可能是痛苦和不方便的。另一方面，微针可以为胰岛素给药提供一种无痛且可能更有效的替代方案。

疫苗接种计划

微针也正在被研究用于输送疫苗 (4). 微针可将疫苗直接输送到富含免疫力的皮肤层，从而增强免疫反应。此外，微针的易用性和无痛性也使其成为大规模疫苗接种计划的一个极具吸引力的选择。

局部麻醉

微针已成功用于局部麻醉 (5)。微针可将麻醉剂直接注射到所需部位，提供快速有效的麻痹，而不会产生传统针头所带来的疼痛。 (5).

微针（化妆品）

微针也正在被研究用于疫苗的递送 (6). 2006 年,德斯蒙德-费尔南德斯博士（Dr. Desmond Fernandes）开发的第一台微针设备上市 (7),该设备成为现代的 Dermaroller。该设备的主要用途是利用固体微针更好地渗透护肤品，如促进胶原蛋白生成的精华素，帮助消除疤痕。

生物传感和医疗点诊断

微针可用于对皮肤中存的间质液或生物标记物进行微创采样。这些生物标记物可用于诊断目的，如监测用于糖尿病管理的葡萄糖水平或检测其他分析物。

微针的优点

从患者和治疗的角度来看，使用微针都有许多好处。

减轻疼痛和不适

对于需要频繁注射但又害怕打针的患者来说，微针是一种极佳的选择。微针非常细小，可以穿透皮肤而不会造成任何疼痛。研究表明，与传统皮下注射针相比，微针可将疼痛感降低 90% (8).

增加药物吸收

微针可穿透皮肤外层屏障，直接将药物输送到真皮层。真皮层血管丰富，能更快更有效地吸收药物。此外，通过微针给药避免了第一次通过代谢，这会降低某些药物的有效性。

副作用更小

微针贴片递送方法针对皮肤的免疫系统，以较低的疫苗剂量产生更强的免疫反应。这导致更有效地使用抗原 (9).

简单、独立的自我治疗

传统的皮下注射针头可能会导致意外的针头伤害、多次使用的污染风险和故意滥用，与此不同，廉价的一次性贴片形式的微针装置有可能在没有临床专业知识的情况下安全使用。

微针给药面临的挑战和未来发展方向

尽管微针取得了重大进展，但在被广泛采用之前，仍有一些挑战需要克服。

 

安全和监管问题

首先，需要解决安全和监管问题。虽然人们普遍认为微针是安全的，但还需要不断进行研究，以评估其长期安全性，特别是长期使用时的安全性。此外，还需要制定明确的监管准则，以确保微针产品的质量和安全。

可扩展性和成本效益

另一个挑战在于微针生产的可扩展性和成本效益。目前的生产工艺可能既复杂又昂贵，这可能会限制其广泛应用。目前正在努力开发可扩展且具有成本效益的制造方法，如光刻和3D打印(10),以克服这一挑战。

微针的稳定性和精确涂层

为确保微针的有效性，微针必须在整个储存、处理和应用过程中保持机械稳定性。在微针上涂抹药物、疫苗或其他生物制剂对保持微针的功能至关重要，但也会带来一些问题，如碳水化合物和聚合物加热，可能导致药物在高温下成型时分解 (11). 此外，微针的精确涂层和治疗物质的输送控制也是一项挑战。研究人员正在努力提高治疗物质的稳定性，优化微针本身 (12), 以及提高微针涂层的精确性和均匀性。

SCIENION微量喷点技术在微针涂层中的应用

微针涂层的方法多种多样，包括浸涂、滚涂或刷涂、喷涂和静电涂层(13).

Tyndall National Institute的最新研究 (14) 将 SCIENION 的微量喷点技术作为一种快速、精确和有效的微针涂层方法进行了研究。该方法在微针表面涂抹配方时表现出了极高的精确度。此外，考虑到可扩展性、生产速度和成本效益等因素，压电喷墨系统在大规模生产方面前景广阔。

结论

微针有可能彻底改变药物递送和诊断领域，提供一种无痛、高效的皮肤给药方法。微针具有减轻疼痛、增加药物吸收和提高病人依从性等优点，因此有望成为传统注射方法的替代品。目前的研发工作主要集中在解决与微针技术相关的挑战上，如安全问题、成本效益和稳定性。随着喷墨涂层等技术的不断进步，微针有可能改变我们提供药物的方式，为个性化医疗和改善患者预后开辟新的可能性。

 

参考文献

(1) Gerstel, M. S., & Place, V. A. (1976). Drug Delivery Device. Google Patents. US Patent No. US3964482A.

(2) Mark Prausnitz | School of Chemical and Biomolecular Engineering (gatech.edu)

(3) Jana, B. A., & Wadhwani, A. D. (2019). Microneedle – Future prospect for efficient drug delivery in diabetes management. Indian journal of pharmacology, 51(1), 4–10. https://doi.org/10.4103/ijp.IJP_16_18

(4) Sheng, T., Luo, B., Zhang, W., Ge, X., Yu, J., Zhang, Y., & Gu, Z. (2021). Microneedle-Mediated Vaccination: Innovation and Translation. Advanced drug delivery reviews, 179, 113919. https://doi.org/10.1016/j.addr.2021.113919

(5) Lee, B. M., Lee, C., Lahiji, S. F., Jung, U. W., Chung, G., & Jung, H. (2020). Dissolving Microneedles for Rapid and Painless Local Anesthesia. Pharmaceutics, 12(4), 366. https://doi.org/10.3390/pharmaceutics12040366

(6) Doddaballapur S. (2009). Microneedling with dermaroller. Journal of cutaneous and aesthetic surgery, 2(2), 110–111. https://doi.org/10.4103/0974-2077.58529

(7) Fernandes, D. (2005). Minimally invasive percutaneous collagen induction. Oral and Maxillofacial Surgery Clinics, 17(1), 51-63.

(8) Gill, H. S., Denson, D. D., Burris, B. A., & Prausnitz, M. R. (2008). Effect of microneedle design on pain in human volunteers. The Clinical journal of pain, 24(7), 585–594. https://doi.org/10.1097/AJP.0b013e31816778f9

(9) Vrdoljak A. Review of recent literature on microneedle vaccine delivery technologies. Vaccine: Development and Therapy. 2013;3:47-55
https://doi.org/10.2147/VDT.S34682

(10) Gülçür, M., Romano, J. M., Penchev, P., Gough, T., Brown, E., Dimov, S., & Whiteside, B. (2021). A cost-effective process chain for thermoplastic microneedle manufacture combining laser micro-machining and micro-injection moulding. CIRP Journal of Manufacturing Science and Technology, 32, 311-321.

(11) Donnelly, R. F., Morrow, D. I., Singh, T. R., Migalska, K., McCarron, P. A., O’Mahony, C., & Woolfson, A. D. (2009). Processing difficulties and instability of carbohydrate microneedle arrays. Drug development and industrial pharmacy, 35(10), 1242–1254. https://doi.org/10.1080/03639040902882280

(12) Lee, J. W., Park, J. H., & Prausnitz, M. R. (2008). Dissolving microneedles for transdermal drug delivery. Biomaterials, 29(13), 2113–2124. https://doi.org/10.1016/j.biomaterials.2007.12.048

(13) Ingrole, R. S. J., & Gill, H. S. (2019). Microneedle Coating Methods: A Review with a Perspective. The Journal of pharmacology and experimental therapeutics, 370(3), 555–569. https://doi.org/10.1124/jpet.119.258707

(14) O’Mahony, C., Hilliard, L., Kosch, T., Bocchino, A., Sulas, E., Kenthao, A., … & Bared, G. (2017). Accuracy and feasibility of piezoelectric inkjet coating technology for applications in microneedle-based transdermal delivery. Microelectronic Engineering, 172, 19-25.

(15) Rad, Z. F., Prewett, P. D., & Davies, G. J. (2021). An overview of microneedle applications, materials, and fabrication methods. Beilstein Journal of Nanotechnology, 12(1), 1034-1046.

Turner, J. G., White, L. R., Estrela, P., & Leese, H. S. (2021). Hydrogel‐forming microneedles: current advancements and future trends. Macromolecular Bioscience, 21(2), 2000307.