sciDROP PICO – drop-on-demand dispensing of pico- and nanoliters

Technology Description & Benefits

SCIENION’s sciDROP PICO is a state of the art non-contact dispensing technology based on piezo driven pulses on an inert glass capillary. This enables accurate and precise droplet deposition under various conditions.  All Piezo Dispense Capillaries (PDCs) feature full aspirate and dispense liquid handling capabilities at the picoliter scale. The sciDROP PICO option, together with SCIENION´s surface coating technology, provides access to a broad field of applications with high accuracy and precision dispensing a wide range of liquids: biomolecules using water based printing buffers, small molecules using a range of organic solvents, as well as a number of various viscous liquids.

The technology is based on a ceramic piezo element that is fitted around a glass capillary. The piezo element is triggered by an electrical pulse which, in turn, leads to a contraction of the ceramic.  This creates a gentle wave inside the capillary that forces out a small drop of sample from the orifice of the PDC.


Benefits of sciDROP PICO:

  • Gentle dispensing of samples without any sheer stress makes it possible to even dispense living cells
  • No glycerol necessary in the system liquid formulation
  • Precise drop volume control with unique visual detection
  • Absolute zero dead volume enabled using Air-Gap dispensing
  • No crystallization of sample inside the tip due to a round orifice
  • No satellite drops due to full drop ejection parameters control

Technical Information Piezo Dispense Capillary (PDC)

Piezo dispensing:


Capillary orifice:

35 - 75 µm

Spot frequency:

200 - 1500 Hz

Typical spot size:

80 - 250 µm

Average CV of drop volumes:

<2%, typically < 0.5 %

Typical pitch (spacing):

freely scalable (> 50 µm)

Capillary materials:

borosilicate glass, TEFLON® tube, PEEK fitting

(contacting medium)

PEEK, stainless steel, corundum

Viscosity of spotable media:

0.4 - 5 (mPa.s)

Piezo Dispense Capillaries & Coatings

PDC 40:

100-150 pl

PDC 50:

150-220 pl

PDC 60:

220-300 pl

PDC 70:

300-360 pl

PDC 80:

360-440 pl

PDC 90:

440-520 pl

PDC 100:

520-600 pl

PDC 110:

600-800 pl

PDC coating type 1:

aqueous solutions (e.g. oligonucleotides)
and organic solvents

PDC coating type 2:

samples containing organic solvents
like DMSO, DMF etc. and protein mixtures
(lysates, allergens etc.)

PDC coating type 3:

samples containing protein solutions and
organic solvents like methanol, isopropanol,
acetonitrile etc.)

PDC coating type 4:

protein solutions and Sol-Gel samples

PDC coating special:

modified according customers requirements and specifications

sciDROP PICO in action