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HTS of protein-protein interactions in mammalian cells using transfected cell arrays

Investigation of protein-protein interactions (PPI) within cells is essential for the elucidation of biological processes and cellular networks.

The two-hybrid system is the most commonly used method for PPI analysis.

A high-throughput, cost effective method for analysing PPI directly in mammalian cells was established: the cell array-based protein-protein interaction assay (CAPPIA).